Spalding Lab
Laboratory of Professor Kirsty L. Spalding, Karolinska Institutet
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In short
In short
The Spalding research group investigates multiple aspects of human adipose biology, with a particular interest in the normal and pathological functioning of adipocytes in response to overnutrition. With obesity associated diseases, such as cardiovascular disease, type 2 diabetes and cancer increasing at epidemic proportions, my group recognises the strong need to better understand obesity-related disease pathogenesis and develop novel treatment strategies which take into account the obesity component of the disease.
News
News
Spalding Lab participated in SVT's programme Rapport
Spalding Lab participated in SVT's programme Rapport
Sunday the 11th of January 2026
The Spalding lab recently appeared on SVT’s news programme Rapport in a segment covering how a major research programme has been on hold for four years due to unclear legal regulations surrounding the use of tissue from deceased donors. Although Karolinska Institutet has repeatedly requested governmental approval to resume this work, the issue remains unresolved. Rapport’s report highlights the challenges this has created for researchers who rely on these samples. As such, Niels Krämer, a PhD student in the Spalding Lab, has been interviewed. You can watch the segment and read the article here (in Swedish).
Benjamin Dedic successfully defended his PhD
Benjamin Dedic successfully defended his PhD
Friday the 5th of December 2025
Today Benjamin Dedic successfully defended his PhD thesis and has been awarded the title of doctor. His thesis was called 'The Role of the Insulin Receptor in Mature Human Adipocytes'. The opponent during the defence was associate professor Zach Gerhart-Hines from the University of Copenhagen. His examination committee consisted of docent Niklas Mejhert, professor Anna Krook and professor Tore Bengtsson from Stockholm University. You can read the kappa of Benjamin's dissertation here.
Niels Krämer won best oral talk at the bi-annual CMB conference
Niels Krämer won best oral talk at the bi-annual CMB conference
Friday the 28th of November 2025
The bi-annual CMB conference took place over the past two days. Niels Krämer delivered a talk titled “Senescence in Human Adipocytes,” which was awarded the prize for best oral presentation at the conference. In his talk, Niels used the group’s 2021 Nature Medicine publication as a foundation to introduce new work on single‑cell transcriptomics in adipocytes.
New paper on protein normalization using total protein for western blot analysis of human adipocytes
New paper on protein normalization using total protein for western blot analysis of human adipocytes
Monday the 1st of September 2025
Leo Westerberg, Benjamin Dedic, Kirsty Spalding, and colleagues have published a study introducing total protein normalization as a more reliable method for western blot analysis in human adipocytes. Compared to traditional housekeeping proteins, total protein normalization showed lower signal variability and reduced intra- and inter-individual differences, making it a superior reference for protein quantification. The full article can be read here.
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