Spalding Lab
Laboratory of Professor Kirsty L. Spalding, Karolinska Institutet
Laboratory of Professor Kirsty L. Spalding, Karolinska Institutet
The Spalding research group investigates multiple aspects of human adipose biology, with a particular interest in the normal and pathological functioning of adipocytes in response to overnutrition. With obesity associated diseases, such as cardiovascular disease, type 2 diabetes and cancer increasing at epidemic proportions, my group recognises the strong need to better understand obesity-related disease pathogenesis and develop novel treatment strategies which take into account the obesity component of the disease.
Friday the 5th of December 2025
Today Benjamin Dedic successfully defended his PhD thesis and has been awarded the title of doctor. His thesis was called 'The Role of the Insulin Receptor in Mature Human Adipocytes'. The opponent during the defence was associate professor Zach Gerhart-Hines from the University of Copenhagen. His examination committee consisted of docent Niklas Mejhert, professor Anna Krook and professor Tore Bengtsson from Stockholm University. You can read the kappa of Benjamin's dissertation here.
Monday the 1st of September 2025
Leo Westerberg, Benjamin Dedic, Kirsty Spalding, and colleagues have published a study introducing total protein normalization as a more reliable method for western blot analysis in human adipocytes. Compared to traditional housekeeping proteins, total protein normalization showed lower signal variability and reduced intra- and inter-individual differences, making it a superior reference for protein quantification. The full article can be read here.
Tuesday the 13th of August 2024
Benjamin Dedic, Leo Westerberg, Andrea Mosqueda SolĂs, Kirsty Spalding and collaborators have recently published a research article on senescence detection using reflected light. In this paper they describe how senescence-associated beta-galactosidase can be accurately measured using confocal microscopy. In addition this staining can now be paired with antibody labeling. Combined this unlocks new research possibilities for understanding cellular senescence. The article can be read here.
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