1. White adipocyte dysfunction and obesity-associated pathologies in humans.

Hagberg CE, Spalding KL.

Philosophical transactions B, 2023 Aug. doi: https://doi.org/10.1098/rstb.2022.0202

2. Implication of lipid turnover for thecontrol of energy balance

Bernard S., Spalding, KL.

Philosophical transactions B, 2023 Aug. doi: https://doi.org/10.1098/rstb.2022.0202

3. A DNA methylation atlas of normal human cell types

Loyfer N, Magenheim J, Peretz A, Cann G, Bredno J, Klochendler A, Fox-Fisher I, Shabi-Porat S, Hecht M, Pelet T, Moss J, Drawshy Z, Amini H, Moradi P, Nagaraju S, Bauman D, Shveiky D, Porat S, Dior U, Rivkin G, Or O, Hirshoren N, Carmon E, Pikarsky A, Khalaileh A, Zamir G, Grinbaum R, Abu Gazala M, Mizrahi I, Shussman N, Korach A, Wald O, Izhar U, Erez E, Yutkin V, Samet Y, Rotnemer Golinkin D, Spalding KL, Druid H, Arner P, Shapiro AMJ, Grompe M, Aravanis A, Venn O, Jamshidi A, Shemer R, Dor Y, Glaser B, Kaplan T. 

Nature. 2023 Jan 4:1–10. doi: 10.1038/s41586-022-05580-6.

PMID: 36599988; PMCID: PMC9811898. 

4. The regulation of adipocyte growth in white adipose tissue

Li Q, Spalding KL. 

Front Cell Dev Biol. 2022 Nov 22;10:1003219. doi: 10.3389/fcell.2022.1003219. 

PMID: 36483678

5. Profiling hypertrophic adipocytes in humans, from transcriptomics to diagnostics

Li Q, Spalding KL. 

EBioMedicine. 2022 Jul;81:104105. doi: 10.1016/j.ebiom.2022.104105. Epub 2022 Jun 20. 

PMID: 35738046; PMCID: PMC9228279.

6. Elevated brain-derived cell-free DNA among patients with first psychotic episode - a proof-of-concept study

Lubotzky A, Pelov I, Teplitz R, Neiman D, Smadja A, Zemmour H, Piyanzin S, Ochana BL, Spalding KL, Glaser B, Shemer R, Dor Y, Kohn Y. 

Elife. 2022 Jun 14;11:e76391. doi: 10.7554/eLife.76391. 

PMID: 35699419; PMCID: PMC9203052.

7. Liquid biopsy reveals collateral tissue damage in cancer.

Lubotzky A, Zemmour H, Neiman D, Gotkine M, Loyfer N, Piyanzin S, Ochana BL, Lehmann-Werman R, Cohen D, Moss J, Magenheim J, Loftus MF, Brais L, Ng K, Mostoslavsky R, Wolpin BM, Zick A, Maoz M, Grinshpun A, Kustanovich A, Makranz C, Cohen JE, Peretz T, Hubert A, Temper M, Salah A, Avniel-Polak S, Grozinsky-Glasberg S, Spalding KL, Rokach A, Kaplan T, Glaser B, Shemer R, Dor Y. 

JCI Insight. 2022 Jan 25;7(2):e153559. doi: 10.1172/jci.insight.153559. 

PMID: 35076021; PMCID: PMC8855834.

8. Radiocabon dating

Smith U, Li Q, Rydén M, Spalding KL, I Hajdas, PAscough, MH Garnett, SJ Fallon, CL Pearson, G Quarta, KL Spalding, H Yamaguchi, M Yoneda

Nat Rev Methods Primers 1, 62 (2021). https://doi.org/10.1038/s43586-021-00058-7

PMID: 

9. Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce 

Li Q, Hagberg CE, Silva Cascales H, Lang S, Hyvönen MT, Salehzadeh F, Chen P, Alexandersson I,Terezaki E, Harms MJ, Kutschke M, Arifen N, Krämer N, Aouadi M, Knibbe C, Boucher J, Thorell A, Spalding Kirsty L

Nat Med. 2021 Oct 4. doi: 10.1038/s41591-021-01501-8. Epub ahead of print. 

PMID: 34608330. 

10. Cellular senescence and its role in white adipose tissue.

Smith U, Li Q, Rydén M, Spalding KL.

Int J Obes (Lond). 2021 Jan 28. doi: 10.1038/s41366-021-00757-x. Online ahead of print.

PMID: 33510393 Review.

11. Practical Guidelines for Optimization and Characterization of the Beckman Coulter CytoFLEX™ Platform.

Bhowmick D, Sheridan RTC, Bushnell TP, Spalding KL.

Cytometry A. 2020 Aug;97(8):800-810. doi: 10.1002/cyto.a.23998. Epub 2020 Mar 9.

PMID: 32150325

12. Adipose lipid turnover and long-term changes in body weight.

Arner P, Bernard S, Appelsved L, Fu KY, Andersson DP, Salehpour M, Thorell A, Rydén M, Spalding KL.

Nat Med. 2019 Sep;25(9):1385-1389. doi: 10.1038/s41591-019-0565-5. Epub 2019 Sep 9.

PMID: 31501613

13. Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes.

Harms MJ, Li Q, Lee S, Zhang C, Kull B, Hallen S, Thorell A, Alexandersson I, Hagberg CE, Peng XR, Mardinoglu A, Spalding KL, Boucher J.

Cell Rep. 2019 Apr 2;27(1):213-225.e5. doi: 10.1016/j.celrep.2019.03.026.

PMID: 30943403

14. Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease.

Moss J, Magenheim J, Neiman D, Zemmour H, Loyfer N, Korach A, Samet Y, Maoz M, Druid H, Arner P, Fu KY, Kiss E, Spalding KL, Landesberg G, Zick A, Grinshpun A, Shapiro AMJ, Grompe M, Wittenberg AD, Glaser B, Shemer R, Kaplan T, Dor Y.

Nat Commun. 2018 Nov 29;9(1):5068. doi: 10.1038/s41467-018-07466-6.

PMID: 30498206 Free PMC article.

15. Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue.

Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P, Rydén M.

Cell Rep. 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069.

PMID: 30332637

16. Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity.

Hagberg CE, Li Q, Kutschke M, Bhowmick D, Kiss E, Shabalina IG, Harms MJ, Shilkova O, Kozina V, Nedergaard J, Boucher J, Thorell A, Spalding KL.

Cell Rep. 2018 Sep 4;24(10):2746-2756.e5. doi: 10.1016/j.celrep.2018.08.006.

PMID: 30184507 Free PMC article.

17. Impact of fat mass and distribution on lipid turnover in human adipose tissue.

Spalding KL, Bernard S, Näslund E, Salehpour M, Possnert G, Appelsved L, Fu KY, Alkass K, Druid H, Thorell A, Rydén M, Arner P.

Nat Commun. 2017 May 23;8:15253. doi: 10.1038/ncomms15253.

PMID: 28534500 Free PMC article.

18. Identification of tissue-specific cell death using methylation patterns of circulating DNA.

Lehmann-Werman R, Neiman D, Zemmour H, Moss J, Magenheim J, Vaknin-Dembinsky A, Rubertsson S, Nellgård B, Blennow K, Zetterberg H, Spalding K, Haller MJ, Wasserfall CH, Schatz DA, Greenbaum CJ, Dorrell C, Grompe M, Zick A, Hubert A, Maoz M, Fendrich V, Bartsch DK, Golan T, Ben Sasson SA, Zamir G, Razin A, Cedar H, Shapiro AM, Glaser B, Shemer R, Dor Y.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1826-34. doi: 10.1073/pnas.1519286113. Epub 2016 Mar 14.

PMID: 26976580 Free PMC article.

19. Detection and Phenotypic Characterization of Adult Neurogenesis.

Kuhn HG, Eisch AJ, Spalding K, Peterson DA.

Cold Spring Harb Perspect Biol. 2016 Mar 1;8(3):a025981. doi: 10.1101/cshperspect.a025981.

PMID: 26931327 Free PMC article. Review.

20. Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis.

Rydén M, Uzunel M, Hård JL, Borgström E, Mold JE, Arner E, Mejhert N, Andersson DP, Widlund Y, Hassan M, Jones CV, Spalding KL, Svahn BM, Ahmadian A, Frisén J, Bernard S, Mattsson J, Arner P.

Cell Metab. 2015 Sep 1;22(3):408-17. doi: 10.1016/j.cmet.2015.06.011. Epub 2015 Jul 16.

PMID: 26190649

21. Adult Neurogenesis in Humans.

Bergmann O, Spalding KL, Frisén J.

Cold Spring Harb Perspect Biol. 2015 Jul 1;7(7):a018994. doi: 10.1101/cshperspect.a018994.

PMID: 26134318 Free PMC article. Review.

22. Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis.

Abreu-Vieira G, Hagberg CE, Spalding KL, Cannon B, Nedergaard J.

Am J Physiol Endocrinol Metab. 2015 May 1;308(9):E822-9. doi: 10.1152/ajpendo.00494.2014. Epub 2015 Mar 3.

PMID: 25738783

23. Maintenance of white adipose tissue in man.

Hyvönen MT, Spalding KL.

Int J Biochem Cell Biol. 2014 Nov;56:123-32. doi: 10.1016/j.biocel.2014.09.013. Epub 2014 Sep 20.

PMID: 25240584 Review.

24. Analysis of radiocarbon, stable isotopes and DNA in teeth to facilitate identification of unknown decedents.

Alkass K, Saitoh H, Buchholz BA, Bernard S, Holmlund G, Senn DR, Spalding KL, Druid H.

PLoS One. 2013 Jul 29;8(7):e69597. doi: 10.1371/journal.pone.0069597. Print 2013.

PMID: 23922751 Free PMC article.

25. Adipocyte triglyceride turnover and lipolysis in lean and overweight subjects.

Rydén M, Andersson DP, Bernard S, Spalding K, Arner P.

J Lipid Res. 2013 Oct;54(10):2909-13. doi: 10.1194/jlr.M040345. Epub 2013 Jul 30.

PMID: 23899442 Free PMC article.

26. Dynamics of hippocampal neurogenesis in adult humans.

Spalding KL, Bergmann O, Alkass K, Bernard S, Salehpour M, Huttner HB, Boström E, Westerlund I, Vial C, Buchholz BA, Possnert G, Mash DC, Druid H, Frisén J.

Cell. 2013 Jun 6;153(6):1219-1227. doi: 10.1016/j.cell.2013.05.002.

PMID: 23746839 Free PMC article.

27. Adipocyte triglyceride turnover is independently associated with atherogenic dyslipidemia.

Frayn K, Bernard S, Spalding K, Arner P.

J Am Heart Assoc. 2012 Dec;1(6):e003467. doi: 10.1161/JAHA.112.003467. Epub 2012 Dec 19.

PMID: 23316323 Free PMC article.

28. Personal identification of cold case remains through combined contribution from anthropological, mtDNA, and bombpulse dating analyses.

Speller CF, Spalding KL, Buchholz BA, Hildebrand D, Moore J, Mathewes R, Skinner MF, Yang DY.

J Forensic Sci. 2012 Sep;57(5):1354-60. doi: 10.1111/j.1556-4029.2012.02223.x. Epub 2012 Jul 16.

PMID: 22804335 Free PMC article.

29. The age of olfactory bulb neurons in humans.

Bergmann O, Liebl J, Bernard S, Alkass K, Yeung MS, Steier P, Kutschera W, Johnson L, Landén M, Druid H, Spalding KL, Frisén J.

Neuron. 2012 May 24;74(4):634-9. doi: 10.1016/j.neuron.2012.03.030.

PMID: 22632721

30. Dynamics of human adipose lipid turnover in health and metabolic disease.

Arner P, Bernard S, Salehpour M, Possnert G, Liebl J, Steier P, Buchholz BA, Eriksson M, Arner E, Hauner H, Skurk T, Rydén M, Frayn KN, Spalding KL.

Nature. 2011 Sep 25;478(7367):110-3. doi: 10.1038/nature10426.

PMID: 21947005 Free PMC article.

31. Analysis of 14C and 13C in teeth provides precise birth dating and clues to geographical origin.

Alkass K, Buchholz BA, Druid H, Spalding KL.

Forensic Sci Int. 2011 Jun 15;209(1-3):34-41. doi: 10.1016/j.forsciint.2010.12.002. Epub 2011 Jan 3.

PMID: 21208756 Free PMC article.

32. Year of birth determination using radiocarbon dating of dental enamel.

Buchholz BA, Spalding KL.

Surf Interface Anal. 2010 May 1;42(5):398-401. doi: 10.1002/sia.3093.

PMID: 20976120 Free PMC article.

33. Fat cell turnover in humans.

Arner P, Spalding KL.

Biochem Biophys Res Commun. 2010 May 21;396(1):101-4. doi: 10.1016/j.bbrc.2010.02.165.

PMID: 20494119 Review.

34. Age estimation in forensic sciences: application of combined aspartic acid racemization and radiocarbon analysis.

Alkass K, Buchholz BA, Ohtani S, Yamamoto T, Druid H, Spalding KL.

Mol Cell Proteomics. 2010 May;9(5):1022-30. doi: 10.1074/mcp.M900525-MCP200. Epub 2009 Dec 4.

PMID: 19965905 Free PMC article.

35. Adipocyte turnover: relevance to human adipose tissue morphology.

Arner E, Westermark PO, Spalding KL, Britton T, Rydén M, Frisén J, Bernard S, Arner P.

Diabetes. 2010 Jan;59(1):105-9. doi: 10.2337/db09-0942. Epub 2009 Oct 21.

PMID: 19846802 Free PMC article.

36. Dynamics of fat cell turnover in humans.

Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, Blomqvist L, Hoffstedt J, Näslund E, Britton T, Concha H, Hassan M, Rydén M, Frisén J, Arner P.

Nature. 2008 Jun 5;453(7196):783-7. doi: 10.1038/nature06902. Epub 2008 May 4.

PMID: 18454136

37. Injury-induced retinal ganglion cell loss in the neonatal rat retina.

Spalding KL, Cui Q, Dharmarajan AM, Harvey AR.

Adv Exp Med Biol. 2006;572:447-51. doi: 10.1007/0-387-32442-9_62.

PMID: 17249608 Review. No abstract available.

38. Neocortical neurogenesis in humans is restricted to development.

Bhardwaj RD, Curtis MA, Spalding KL, Buchholz BA, Fink D, Björk-Eriksson T, Nordborg C, Gage FH, Druid H, Eriksson PS, Frisén J.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12564-8. doi: 10.1073/pnas.0605177103. Epub 2006 Aug 10.

PMID: 16901981 Free PMC article.

39. Forensics: age written in teeth by nuclear tests.

Spalding KL, Buchholz BA, Bergman LE, Druid H, Frisén J.

Nature. 2005 Sep 15;437(7057):333-4. doi: 10.1038/437333a.

PMID: 16163340

40. Retrospective birth dating of cells in humans.

Spalding KL, Bhardwaj RD, Buchholz BA, Druid H, Frisén J.

Cell. 2005 Jul 15;122(1):133-43. doi: 10.1016/j.cell.2005.04.028.

PMID: 16009139

41. Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis.

Holmberg J, Armulik A, Senti KA, Edoff K, Spalding K, Momma S, Cassidy R, Flanagan JG, Frisén J.

Genes Dev. 2005 Feb 15;19(4):462-71. doi: 10.1101/gad.326905.

PMID: 15713841 Free PMC article.

42. Retinal ganglion cell neurotrophin receptor levels and trophic requirements following target ablation in the neonatal rat.

Spalding KL, Cui Q, Harvey AR.

Neuroscience. 2005;131(2):387-95. doi: 10.1016/j.neuroscience.2004.11.027.

PMID: 15708481

43. Caspase-independent retinal ganglion cell death after target ablation in the neonatal rat.

Spalding KL, Dharmarajan AM, Harvey AR.

Eur J Neurosci. 2005 Jan;21(1):33-45. doi: 10.1111/j.1460-9568.2004.03826.x.

PMID: 15654841

44. Target-derived and locally derived neurotrophins support retinal ganglion cell survival in the neonatal rat retina.

Spalding KL, Rush RA, Harvey AR.

J Neurobiol. 2004 Sep 5;60(3):319-27. doi: 10.1002/neu.20028.

PMID: 15281070

45. Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells.

Mellough CB, Cui Q, Spalding KL, Symons NA, Pollett MA, Snyder EY, Macklis JD, Harvey AR.

Exp Neurol. 2004 Mar;186(1):6-19. doi: 10.1016/j.expneurol.2003.10.021.

PMID: 14980806

46. Anterograde transport and trophic actions of BDNF and NT-4/5 in the developing rat visual system.

Spalding KL, Tan MM, Hendry IA, Harvey AR.

Mol Cell Neurosci. 2002 Apr;19(4):485-500. doi: 10.1006/mcne.2001.1097.

PMID: 11988017

47. The effects of central administration of neurotrophins or transplants of fetal tectal tissue on retinal ganglion cell survival following removal of the superior colliculus in neonatal rats.

Spalding KL, Cui Q, Harvey AR.

Brain Res Dev Brain Res. 1998 Apr 17;107(1):133-42. doi: 10.1016/s0165-3806(98)00010-8.

PMID: 9602096